Suppression of Cell Proliferation and Macrophage Infiltration with Localized siRNA Delivery in a Murine Model of Intimal Hyperplasia
Intimal hyperplasia limits the durability of peripheral vascular interventions and is associated with cell proliferation and macrophage infiltration. We use an in vivo rat carotid angioplasty model to evaluate inhibition of intimal hyperplasia with localized siRNA delivery targeting Thrombospondin-2 (TSP2) and evaluate its impact on cell proliferation (Ki-67) and macrophage infiltration (CD68).
Source: Journal of Vascular Surgery - Category: Surgery Authors: Jennifer R. Li, Max Zhu, Patric Liang, Kimberly Piper, Mauricio Contreras, Leena Pradhan-Nabzdyk, Frank LoGerfo Tags: PC: Poster Competition Source Type: research