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Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF- κB pathway in ischemia/reperfusion injury after renal transplantation.
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation. Int J Mol Med. 2017 Oct 20;: Authors: Zhang J, Zhao D, Na N, Li H, Miao B, Hong L, Huang Z Abstract Ischemia/reperfusion injury (IRI) commonly occurs in renal transplantation. Erythropoietin (EPO) exerts a protective effect in IRI. To investigate the underlying molecular mechanism, rat models of renal IRI were established and treated with EPO and/or lentivirus‑mediated EPO-siRNA, the signal transducer and activator of transcription 6 (STAT6) inhibito...
Source: International Journal of Molecular Medicine - October 20, 2017 Category: Molecular Biology Authors: Zhang J, Zhao D, Na N, Li H, Miao B, Hong L, Huang Z Tags: Int J Mol Med Source Type: research

Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts.
Abstract Kidney transplantation is an effective final therapeutic procedure for patients with end-stage kidney failure. Although advanced immunosuppressive therapy is administered following transplantation, certain patients still suffer from acute allograft rejection. MicroRNAs (miRs) have a potential diagnostic and therapeutic value for acute renal allograft rejection; however, their underlying mechanism of action is largely unknown. In the present study, an increased level of miR-650 was identified to be associated with the downregulation of B-cell CLL/lymphoma 11B (BCL11B) expression in acute renal allograft ...
Source: International Journal of Molecular Medicine - October 17, 2017 Category: Molecular Biology Authors: Jin P, Chen H, Xie J, Zhou C, Zhu X Tags: Int J Mol Med Source Type: research