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The Myeloid HSF1 ‐Β‐Catenin Axis Regulates NLRP3 Inflammasome Activation in Mouse Liver Ischemia/Reperfusion Injury
Conclusions: The myeloid HSF1‐β‐catenin axis controlled NLRP3 activation by modulating the XBP1 signaling pathway. HSF1 activation promoted β‐catenin, which in turn inhibited XBP1, leading to NLRP3 inactivation and reduced IR‐induced liver injury. Our findings demonstrated that HSF1‐β‐catenin signaling is a novel regulator of innate immunity in liver inflammatory injury and implied the therapeutic potential for the management of sterile liver inflammation in transplant recipients. This article is protected by copyright. All rights reserved.
Source: Hepatology - July 29, 2016 Category: Internal Medicine Authors: Shi Yue, Jianjun Zhu, Ming Zhang, Changyong Li, Xingliang Zhou, Min Zhou, Michael Ke, Ronald W. Busuttil, Qilong Ying, Jerzy W. Kupiec ‐Weglinski, Qiang Xia, Bibo Ke Tags: Liver Injury and Regeneration Source Type: research

Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research