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Cognitive improvement following ischemia/reperfusion injury induced by voluntary running ‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition.
Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. Int J Mol Med. 2018 Feb 12;: Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Abstract Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be as...
Source: International Journal of Molecular Medicine - February 12, 2018 Category: Molecular Biology Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Tags: Int J Mol Med Source Type: research

Repression of the Equilibrative Nucleoside Transporters Dampens Inflammatory Lung Injury.
Conclusions: Our findings reveal transcriptional repression of ENTs as innate protective response during acute pulmonary inflammation. The inhibition of ENTs could be pursued as therapeutic option to ameliorate inflammatory lung injury. PMID: 23590299 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - April 3, 2013 Category: Molecular Biology Authors: Morote-Garcia JC, Köhler D, Roth JM, Mirakaj V, Eldh T, Eltzschig HK, Rosenberger P Tags: Am J Respir Cell Mol Biol Source Type: research