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The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression Gene Regulation
The mechanisms whereby progesterone (P4), acting via the progesterone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompletely defined. Using immortalized human myometrial (hTERT-HM) cells stably expressing wild-type PR-A or PR-B (PRWT), we found that P4 significantly inhibited IL-1β induction of the NF-κB target genes, COX-2 and IL-8. P4–PRWT transrepression occurred at the level of transcription initiation and was mediated by decreased recruitment of NF-κB p65 and RNA polymerase II to COX-2 and IL-8 promoters. However, in cells stably expressing a PR-A or PR-B DNA-binding...
Source: Journal of Biological Chemistry - July 28, 2017 Category: Chemistry Authors: Chien-Cheng Chen, Alina P. Montalbano, Imran Hussain, Wan-Ru Lee, Carole R. Mendelson Tags: Gene Regulation Source Type: research
