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siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery.
Abstract As the population ages, brain pathologies such as neurodegenerative diseases and brain cancer increase their incidence, being the need to find successful treatments of upmost importance. Drug delivery to the central nervous system (CNS) is required in order to reach diseases causes and treat them. However, biological barriers, mainly blood-brain barrier (BBB), are the key obstacles that prevent the effectiveness of possible treatments due to their ability to strongly limit the perfusion of compounds into the brain. Over the past decades, new approaches towards overcoming BBB and its efflux transporters ha...
Source: Ageing Research Reviews - March 18, 2015 Category: Genetics & Stem Cells Authors: Gomes MJ, Martins S, Sarmento B Tags: Ageing Res Rev Source Type: research