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GSE140729 Structure of LINC00511-siRNA-conjugated nanobubbles and improvement of cisplatin sensitivity on triple negative breast cancer
Contributors : Bolin Wu ; Yanchi Yuan ; Erjing Li ; Hui Jing ; Wen ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the present study, we prepared a novel theranostic agent loaded with LINC00511-siRNA, which not only can serve as the siRNA delivery platform but also as the UCA for contrast enhanced ultrasound (CEUS). Combined with low-frequency ultrasound exposure, the novel theranostic agent achieves the controlled release of LINC00511-siRNA and facilitates the transfection of LINC00511-siRNA. Furthermore, in order to investigate how LINC00511 affects drug resistance of TNBC, ...
Source: GEO: Gene Expression Omnibus - September 3, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Nucleic acids-based nanotherapeutics crossing the blood brain barrier.
Abstract The restless endeavors revealing the molecular pathways underlying many neurodegenerative diseases and brain tumors have paved the way for the introduction of the selective exogenous gene-based therapeutics. The implicated active biomolecules encompass mainly negatively-charged nucleic acids ranging from DNA, mRNA, non-coding RNAs (small-interfering RNA, siRNA, and microRNA, miRNA), to antisense oligonucleotides. They selectively interfere with the genes translational and/or transcriptional processes. Although many reviews previously addressed brain targeting, a thorough correlation between the molecular ...
Source: Current Gene Therapy - May 10, 2017 Category: Genetics & Stem Cells Authors: Nafee N, Gouda N Tags: Curr Gene Ther Source Type: research