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Total 92 results found since Jan 2013.
Chitosan nanoparticle carrying small interfering RNA to platelet-derived growth factor B mRNA inhibits proliferation of smooth muscle cells in rabbit injured arteries.
In conclusion, transfection of chitosan nanoparticle carrying siRNA against PDGF-B mRNA could inhibit proliferation of vSMCs in the rabbit iliac artery injury model.
PMID: 23518855 [PubMed - as supplied by publisher]
Source: Vascular - March 21, 2013 Category: Surgery Authors: Xia H, Jun J, Wen-Ping L, Yi-Feng P, Xiao-Ling C Tags: Vascular Source Type: research
A new method of ultrasonic nonviral gene delivery to the adult myocardium
Abstract: Cardiac gene transfer is a powerful molecular tool to improve our understanding of the role of new proteins and mutants in cardiac pathophysiology. There is a need for a simple efficient myocardial gene delivery technique in order to study the physiological role of proteins in their native environment. Here we tested a new method of myocardial nonviral gene delivery, by using the combination of ultrasound energy (USE), liposomes and high pressure injections to the rat heart. Wistar rats were subjected to intra-myocardial injections of liposomes-DNA or siRNA mix. The heart was exposed after an inter-costal incisio...
Source: Journal of Molecular and Cellular Cardiology - August 6, 2012 Category: Cytology Authors: Youakim Saliba, Nathalie Mougenot, Adeline Jacquet, Fabrice Atassi, Stéphane Hatem, Nassim Farès, Anne-Marie Lompré Tags: Original Articles Source Type: research
