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Superparamagnetic iron oxide nanoparticles target BxPC-3 cells and silence MUC4 for theranostics of pancreatic cancer
CONCLUSION: PEI-SPION-siRNA may be beneficial as a novel theranostic tool for PC.PMID:37236323 | DOI:10.1016/j.bbagen.2023.130383
Source: Biochimica et Biophysica Acta - May 26, 2023 Category: Biochemistry Authors: Yu Pu Helin Ke Changqiang Wu Shaodan Xu Yang Xiao Lina Han Guorong Lyv Shilin Li Source Type: research

Synthesis and Characterization of Mn:ZnSe/ZnS/ZnMnS Sandwiched QDs for Multimodal Imaging and Theranostic Applications
In this work, a facile aqueous synthesis method is optimized to produce Mn:ZnSe/ZnS/ZnMnS sandwiched quantum dots (SQDs). In this core–shell co‐doped system, paramagnetic Mn2+ ions are introduced as core and shell dopants to generate Mn phosphorescence and enhance the magnetic resonance imaging signal, respectively. T1 relaxivity of the nanoparticles can be improved and manipulated by raising the shell doping level. Steady state and time‐resolved optical measurements suggest that, after high level shell doping, Mn phosphorescence of the core can be sustained by the sandwiched ZnS shell. Because the SQDs are free of t...
Source: Small - December 10, 2015 Category: Nanotechnology Authors: Yucheng Wang, Bo Wu, Chengbin Yang, Maixian Liu, Tze Chien Sum, Ken‐Tye Yong Tags: Full Paper Source Type: research