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Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle ‐Based Small Interfering RNA
ConclusionIA delivery of the periostin –siRNA nanocomplex represents a promising clinical approach to mitigate the severity of joint degeneration in OA. Our findings may thus provide an unequivocal scientific rationale for longitudinal studies of this approach. Utilizing a cartilage-specific gene-knockout strategy will further illumina te the functional role of periostin in OA.
Source: Arthritis and Rheumatology - October 28, 2021 Category: Rheumatology Authors: Xin Duan, Lei Cai, Christine T. N. Pham, Yousef Abu ‐Amer, Hua Pan, Robert H. Brophy, Samuel A. Wickline, Muhammad Farooq Rai Tags: Full Length Source Type: research

The Discoidin Domain Receptor 2/Annexin A2/Matrix Metalloproteinase 13 Loop Promotes Joint Destruction in Arthritis Through Promoting Migration and Invasion of Fibroblast‐like Synoviocytes
ConclusionAnnexin A2 is a key molecule in the DDR‐2/annexin A2/MMP‐13 loop, the activation of which contributes to joint destruction in RA, mainly through promoting invasion of FLS. Annexin A2 might therefore become a novel clinical target for RA treatment.
Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Wei Zhao, Cun Zhang, Man Shi, Jian Zhang, Meng Li, Xiaochang Xue, Zhao Zhang, Zhen Shu, Jinyu Zhu, Nan Mu, Weina Li, Qiang Hao, Zhijun Wang, Li Gong, Wei Zhang, Yingqi Zhang Tags: Rheumatoid Arthritis Source Type: research