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Canstatin modulates L-type calcium channel activity in rat ventricular cardiomyocytes.
Abstract Excessive increase of cytosolic Ca2+ through the activation of L-type Ca2+ channels (LTCCs) via β adrenergic receptor induces apoptosis of cardiomyocytes. Canstatin, a cleaved fragment of collagen type IV α2 chain, is abundantly expressed in normal heart tissue. We previously reported that canstatin inhibits β adrenergic receptor-stimulated apoptosis in cardiomyoblasts. Here, we tested the hyposeis that canstatin regulates LTCCs activity in ventricular cardiomyocytes. Collagen type IV α2 chain (COL4A2) small interfering (si) RNA (for canstatin suppression) or control siRNA was injected via jugular vei...
Source: Biochemical and Biophysical Research communications - April 4, 2018 Category: Biochemistry Authors: Imoto K, Hirakawa M, Okada M, Yamawaki H Tags: Biochem Biophys Res Commun Source Type: research