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Evaluation of liver specific ionizable lipid nanocarrierin the delivery of siRNA
Chem Phys Lipids. 2022 May 24:105207. doi: 10.1016/j.chemphyslip.2022.105207. Online ahead of print.ABSTRACTHepcidin, a key regulator of iron homeostasis, has been implicated in the pathogenesis of various iron-related diseases. Although small interfering RNA (siRNA) are potent to modulate the expression of hepcidin, their bioavailability remains a major issue. The β-galactopyranoside-conjugated liposomes (GAL-liposome) targeting liver synthesized hepcidin were prepared by thin lipid film hydration method to encapsulate siRNA and the conjugation of β-galactopyranoside to the lipid nanocarrier was achieved by covalent che...
Source: Chemistry and Physics of Lipids - May 27, 2022 Category: Lipidology Authors: Shilpa Rana Archana Bhatnagar Suman Singh Nirmal Prabhakar Source Type: research