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Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research

Hypoxia-Inducible Factor-1 α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Neurochem Res. 2021 Sep 23. doi: 10.1007/s11064-021-03454-3. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a common feature of the tumoural environment-is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aim...
Source: Neurochemical Research - September 24, 2021 Category: Neuroscience Authors: Pedro Ozorio Brum Guilherme Danielski Viola Carolina Saibro-Girardi Camila Tiefensee-Ribeiro Matheus Ozorio Brum Juciano Gasparotto Rachel Krolow Jos é Cláudio Fonseca Moreira Daniel Pens Gelain Source Type: research