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Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells
Bioorg Chem. 2022 Sep 28;129:106178. doi: 10.1016/j.bioorg.2022.106178. Online ahead of print.ABSTRACTNeuroinflammation is a leading cause for neurological disorders. Carbazole alkaloids, isolated from the medicinal plants of Murraya species (Rutaceae), have exhibited wide pharmacological activities particularly for neuroinflammation. However, its underlying cellular targets and molecular mechanisms still remain unclear. In current study, we found that murrayafoline A (MA), a carbazole alkaloid obtained from Murraya tetramera, potently inhibited the production of neuroinflammation mediators, such as nitric oxide (NO), TNF-...
Source: Bioorganic Chemistry - October 11, 2022 Category: Chemistry Authors: Chao-Hua Li Ying Zhou Peng-Fei Tu Ke-Wu Zeng Yong Jiang Source Type: research

Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O- β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway Molecules doi: 10.3390/molecules26133852 Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-D-glucopyranoside (MNG, a component of A. ...
Source: Molecules - June 24, 2021 Category: Chemistry Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Tags: Article Source Type: research

Molecules, Vol. 25, Pages 4591: Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells
Kwon Magnolol is a biologically active compound, isolated from the Chinese herb Magnolia, that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic activities. We found that magnolol sensitizes TRAIL-induced apoptotic cell death via upregulation of DR5 and downregulation of cellular FLICE-inhibitory protein (c-FLIP) and Mcl-1 in cancer cells, but not in normal cells. Mechanistically, magnolol increased ATF4-dependent DR5 expression at the transcription level, and knockdown of ATF4 markedly inhibited magnolol-induced DR5 upregulation. Silencing DR5 with siRNA prevented combined treatment with magn...
Source: Molecules - October 8, 2020 Category: Chemistry Authors: Seon Min Woo Kyoung-jin Min Taeg Kyu Kwon Tags: Article Source Type: research

The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts Signal Transduction
In this study, using rat calvarial osteoblast culture and rat bone growth models, we demonstrated that icariin promotes bone formation by activating the cAMP/protein kinase A (PKA)/cAMP response element–binding protein (CREB) pathway requiring functional primary cilia of osteoblasts. We found that icariin increases the peak bone mass attained by young rats and promotes the maturation and mineralization of rat calvarial osteoblasts. Icariin activated cAMP/PKA/CREB signaling of the osteoblasts by increasing intracellular cAMP levels and facilitating phosphorylation of both PKA and CREB. Blocking cAMP/PKA/CREB signaling wit...
Source: Journal of Biological Chemistry - December 22, 2017 Category: Chemistry Authors: Wengui Shi, Yuhai Gao, Yuanyuan Wang, Jian Zhou, Zhenlong Wei, Xiaoni Ma, Huiping Ma, Cory J. Xian, Jufang Wang, Keming Chen Tags: Molecular Bases of Disease Source Type: research

Molecules, Vol. 22, Pages 892: The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153
Garlic is a food and medicinal plant that has been used in folk medicine since ancient times for its beneficial health effects, which include protection against cancer. Crushed garlic cloves contain an array of small sulfur-rich compounds such as ajoene. Ajoene is able to interfere with biological processes and is cytotoxic to cancer cells in the low micromolar range. BisPMB is a synthetic ajoene analogue that has been shown in our laboratory to have superior cytotoxicity to ajoene. In the current study we have performed a DNA microarray analysis of bisPMB-treated WHCO1 oesophageal cancer cells to identify pathways and pro...
Source: Molecules - May 28, 2017 Category: Chemistry Authors: Vuyolwethu Siyo Georgia Sch äfer Roger Hunter Andriy Grafov Iryna Grafova Martin Nieger Arieh A. Katz M. Iqbal Parker Catherine H. Kaschula Tags: Article Source Type: research