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Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway.
In this study, we investigated the protective effects of MLB against inflammation-induced endothelial dysfunction in vitro and in vivo, and the underlying mechanisms. Endothelial dysfunction was induced in human dermal microvascular endothelial cells (HMEC-1) in vitro by lipopolysaccharide (LPS, 1 μg/mL). We showed that pretreatment with MLB (10-100 μM) dose-dependently inhibited LPS-induced upregulation of inflammatory cytokines ICAM1, VCAM1, and TNFα, which contributed to reduced leukocytes adhesion and attenuation of endothelial hyperpermeability in HMEC-1 cells. SD rats were injected with LPS (10 mg/kg, ip) to...
Source: Acta Pharmacologica Sinica - January 7, 2019 Category: Drugs & Pharmacology Authors: Gao F, Li JM, Xi C, Li HH, Liu YL, Wang YP, Xuan LJ Tags: Acta Pharmacol Sin Source Type: research

Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway.
This study provides new insights into the anti-tumor activity of hispidulin in HCC. PMID: 30218072 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - September 14, 2018 Category: Drugs & Pharmacology Authors: Han M, Gao H, Xie J, Yuan YP, Yuan Q, Gao MQ, Liu KL, Chen XH, Han YT, Han ZW Tags: Acta Pharmacol Sin Source Type: research

Ophiopogonin D maintains Ca(2+) homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.
CONCLUSION: OPD is a novel CYP2J3 inducer that may offer a therapeutic benefit in treatment of cardiovascular diseases related to disturbance of Ca(2+) homeostasis and ER stress. PMID: 26838069 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 1, 2016 Category: Drugs & Pharmacology Authors: You WT, Zhou T, Ma ZC, Liang QD, Xiao CR, Tang XL, Tan HL, Zhang BL, Wang YG, Gao Y Tags: Acta Pharmacol Sin Source Type: research