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Source: BMC Cancer
Nutrition: Vitamin C
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Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
Background:
Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal function. Depleted intra-tumoral ascorbic acid may thus play a role in the loss of HIF-1α regulation in melanoma. These studies assess the ability of ascorbic acid to reduce HIF-1α protein and transcriptional activity in metastatic melanoma and reduce its invasive potential.
Methods:
HIF-1α protein was evaluated by wester...
Source: BMC Cancer - November 7, 2015 Category: Cancer & Oncology Authors: Sarah MilesAdam FischerSandeep JoshiRichard Niles Source Type: research
