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Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: Inhibition mediated at the level of transcription of THTR-1 and 2.
Abstract Thiamin (vitamin B1) is essential for normal cellular metabolism and function. Pancreatic acinar cells (PACs) obtain thiamin from circulation, via a specific carrier-mediated process that involves the plasma membrane thiamin transporters -1 and -2 (THTR-1 and THTR-2; products of SLC19A2 and SLC19A3 genes, respectively). There is nothing known about the effect of bacterial products/toxins on thiamin uptake by PACs. We addressed this issue in the current investigation by examining the effect of the bacterial flagellin on physiological and molecular parameters of the thiamin uptake by PACs. We used human pri...
Source: Am J Physiol Gastroi... - March 27, 2019 Category: Gastroenterology Authors: Srinivasan P, Anandam KY, Ramesh V, Geltz ET, Said HM Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research