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The Isothiocyanate Sulforaphane Depends on the Nrf2/ γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal.
The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. Neurochem Res. 2021 Jan 03;: Authors: Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dos Santos Petry F, de Oliveira MR Abstract Methylglyoxal (MG) is a reactive dicarbonyl presenting both endogenous (e.g. glycolysis) and exogenous (e.g. food cooking) sources. MG induces neurotoxicity, at least in part, by affecting mitochondrial function, including a decline in the oxidative phosphorylation (OXPHOS) system activity, bioenergetics failure, and redox disturba...
Source: Neurochemical Research - January 3, 2021 Category: Neuroscience Authors: Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dos Santos Petry F, de Oliveira MR Tags: Neurochem Res Source Type: research