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Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway
In conclusion, apigenin protects cardiomyocyte function from oxidative stress-induced myocardial injury by modulating SIRT1 signaling pathway, which provides a new potential therapeutic natural compound for the clinical treatment of cardiovascular diseases.PMID:36781043 | DOI:10.1016/j.ejphar.2023.175584
Source: European Journal of Pharmacology - February 13, 2023 Category: Drugs & Pharmacology Authors: Kun Xu Yao Yang Ming Lan Jiannan Wang Bing Liu Mingjing Yan Hua Wang Wenlin Li Shenghui Sun Kaiyi Zhu Xiyue Zhang Mingyan Hei Xiuqing Huang Lin Dou Weiqing Tang Qing He Jian Li Tao Shen Source Type: research

The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes.
In conclusion, ellagic acid is an effective skin-whitening agent and might be used as a topical applicant. PMID: 33545118 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S, Hseu YC Tags: Biochem Pharmacol Source Type: research

Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/ Wnt inhibitory factor 1 (WIF1) axis
Conclusion: Taken together, we demonstrated that SFN could suppress the growth of NPC cells via the DNMT1/WIF1 axis.Graphical abstract
Source: Phytomedicine - July 30, 2019 Category: Drugs & Pharmacology Source Type: research