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Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver.
In conclusion, our findings show that CME is the mechanism responsible for the internalization of the canalicular transporters BSEP and MRP2 in E17G-induced cholestasis. The shift of these transporters from raft to non-raft microdomains could be a prerequisite for the transporters to be endocytosed under cholestatic conditions. PMID: 29355600 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 17, 2018 Category: Biochemistry Authors: Miszczuk GS, Barosso IR, Larocca MC, Marrone J, Marinelli RA, Boaglio AC, Sánchez Pozzi EJ, Roma MG, Crocenzi FA Tags: Biochim Biophys Acta Source Type: research

The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism
Abstract: We recently discovered that a signaling lipid, sphingosine-1-phosphate (S1P), generated by sphingosine kinase 1, regulates a major epidermal antimicrobial peptide's [cathelicidin antimicrobial peptide (CAMP)] expression via an NF-κB→C/EBPα-dependent pathway, independent of vitamin D receptor (VDR) in epithelial cells. Activation of estrogen receptors (ERs) by either estrogens or phytoestrogens also is known to stimulate S1P production, but it is unknown whether ER activation increases CAMP production. We investigated whether a phytoestrogen, genistein, simulates CAMP expression in keratinocytes, a model of ep...
Source: The Journal of Nutritional Biochemistry - March 31, 2014 Category: Biochemistry Authors: Kyungho Park, Young-Il Kim, Kyong-Oh Shin, Ho Seong Seo, Jong Youl Kim, Taj Mann, Yuko Oda, Yong-Moon Lee, Walter M. Holleran, Peter M. Elias, Yoshikazu Uchida Tags: Research Articles Source Type: research

Multiple Phytoestrogens Inhibit Cell Growth and Confer Cytoprotection By Inducing Manganese Superoxide Dismutase Expression
Phytoestrogens are of interest because of their reported beneficial effects on many human maladies including cancer, neurodegeneration, cardiovascular disease and diabetes. As data on phytoestrogens continues to accumulate, it is clear that there is significant overlap in the cellular effects elicited by these various compounds. Here, we show that one mechanism by which a number of phytoestrogens achieve their growth inhibitory and cytoprotective effects is via induction of the mitochondrial manganese superoxide dismutase (MnSOD). Eight phytoestrogens, including resveratrol, coumestrol, kaempferol, genistein, daidzein, api...
Source: Phytotherapy Research - March 21, 2013 Category: Biochemistry Authors: Ellen L. Robb, Jeffrey A. Stuart Tags: Research Article Source Type: research