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Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.
Authors: Zhu J, Ren J, Tang L Abstract Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, incre...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research