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Condition: Mitochondrial Disease
Nutrition: Saffron
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Crocin protects PC12 cells against MPP+-induced injury through inhibition of mitochondrial dysfunction and ER stress
Publication date: Available online 21 July 2015 Source:Neurochemistry International Author(s): Guo-Feng Zhang, Yi Zhang, Gang Zhao The molecular machinery that mediates neuronal injury in neurodegenerative conditions such as Parkinson’s disease (PD) remains to be fully deciphered, which will hopefully provide novel therapeutic targets for these disorders. Crocin, one of the water-soluble carotenoids isolated from the Crocus sativus L (saffron) stigma, has been reported to exert therapeutic potential in many disease models. Here, we establish an in vitro PD model using 1-methyl-4-phenylpyridinium (MPP+)-injured PC12 ...
Source: Neurochemistry International - July 22, 2015 Category: Neuroscience Source Type: research
