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The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration
BMB Rep. 2021 Jan 7:5184. Online ahead of print.ABSTRACTVoltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the hi...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Hyun Woo Park Min Seok Song Hun Ju Sim Pan Dong Ryu So Yeong Lee Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration.
Abstract Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the highly expressed Kv2.1 could detect reac...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Park HW, Song MS, Sim HJ, Ryu PD, Lee SY Tags: BMB Rep Source Type: research