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Trek2a regulates gnrh3 expression under control of melatonin receptor Mt1 and α2-adrenoceptor.
Abstract Gonadotrophin-releasing hormone (GnRH) expression is associated with the two-pore domain potassium ion (K+) channel-related K+ (TREK) channel trek2a expression and melatonin levels. We aimed to investigate correlation of trek2a expression with gnrh3 expression, and regulatory mechanisms of trek2a expression by the melatonin receptor Mt1 and α2-adrenoceptor which are regulated by melatonin. trek2a specific siRNA, Mt1 antagonist luzindole and α2-adrenoceptor antagonist prazosin were administered into the adult zebrafish brain and gene expressions were examined by real-time PCR. trek2a specific siRNA admin...
Source: Biochemical and Biophysical Research communications - February 7, 2018 Category: Biochemistry Authors: Loganathan K, Moriya S, Parhar IS Tags: Biochem Biophys Res Commun Source Type: research