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Inhibitory effects of Omega-3 fatty acids on Early Brain Injury after Subarachnoid Hemorrhage in Rats: possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway.
This study was to examine the effects of omega-3 fatty acids on SAH-induced EBI. Two weeks before SAH, 30% Omega-3 fatty acids was administered by oral gavage at 1g/kg body weight once every 24hours. Specific siRNA for GPR120 was exploited. Terminal deoxynucleotidyl transferase dUTP nick end labeling, fluoro-Jade B staining, and neurobehavioral scores and brain water content test showed that omega-3 fatty acids effectively suppressed SAH-induced brain cell apoptosis and neuronal degradation, behavioral impairment, and brain edema. Western blot, immunoprecipitation, and electrophoretic mobility shift assays results showed t...
Source: The International Journal of Biochemistry and Cell Biology - March 17, 2016 Category: Biochemistry Authors: Yin J, Li H, Meng C, Chen D, Chen Z, Wang Y, Wang Z, Chen G Tags: Int J Biochem Cell Biol Source Type: research