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IKK ε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury
This study further revealed the mechanism of IKKε in inflammation and myocardial nutrition deprivation.PMID:34933200 | DOI:10.1016/j.bbrc.2021.12.047
Source: Biochemical and Biophysical Research communications - December 21, 2021 Category: Biochemistry Authors: Ganyi Chen Yueyue Xu Rui Fan Yafeng Liu Yiwei Yao Hongwei Jiang Qiyong Wu Liangpeng Li Wen Chen Xin Chen Source Type: research

Propionate promotes vitamin D receptor expression via yes-associated protein in rats with short bowel syndrome.
In this study, we aimed to investigate the effect of propionate on the expression of the vitamin D receptor (VDR) in the small intestine of rats with SBS. Firstly, IEC-6 (intestinal epithelioid cell line No. 6) cells were incubated in vitro with 1 mM sodium propionate for 24 h. This resulted in a significant increase in the expression of VDR and yes-associated protein (YAP) compared with that in the control group. Transfection of IEC-6 cells with YAP siRNA significantly down-regulated the expression of VDR. By contrast, after incubating IEC-6 cells with lysophosphatidic acid, an agonist of YAP, upregulation of VDR and...
Source: Biochemical and Biophysical Research communications - January 11, 2020 Category: Biochemistry Authors: Lin H, Huang Y, Tian T, Wang P, Li Y Tags: Biochem Biophys Res Commun Source Type: research

The role of a single gene encoding the Single von Willebrand factor C-domain protein (SVC) in bumblebee immunity extends beyond antiviral defense.
Abstract The Single von Willebrand factor C-domain proteins (SVCs) are a group of short proteins mainly found in arthropods. They are proposed to be responsive in relation to environmental challenges including the nutritional status, bacterial and viral infections. The SVC protein Vago acts as a cross-talk molecule between the small interfering RNA (siRNA) pathway and the Jak/STAT pathway upon viral infection in Drosophila melanogaster and Culex mosquito cells. Unlike flies and mosquitoes that possess diverse SVCs, most bee species only have one of which the function remains unclear. Here we investigated whether t...
Source: Insect Biochemistry and Molecular Biology - October 23, 2017 Category: Biochemistry Authors: Wang H, Smagghe G, Meeus I Tags: Insect Biochem Mol Biol Source Type: research