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The role of a single gene encoding the Single von Willebrand factor C-domain protein (SVC) in bumblebee immunity extends beyond antiviral defense.
Abstract The Single von Willebrand factor C-domain proteins (SVCs) are a group of short proteins mainly found in arthropods. They are proposed to be responsive in relation to environmental challenges including the nutritional status, bacterial and viral infections. The SVC protein Vago acts as a cross-talk molecule between the small interfering RNA (siRNA) pathway and the Jak/STAT pathway upon viral infection in Drosophila melanogaster and Culex mosquito cells. Unlike flies and mosquitoes that possess diverse SVCs, most bee species only have one of which the function remains unclear. Here we investigated whether t...
Source: Insect Biochemistry and Molecular Biology - October 23, 2017 Category: Biochemistry Authors: Wang H, Smagghe G, Meeus I Tags: Insect Biochem Mol Biol Source Type: research