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Yangonin protects against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner.
In conclusion, yangonin alleviates estrogen-induced cholestasis, due to FXR-mediated gene regulation. PMID: 31220436 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 16, 2019 Category: Drugs & Pharmacology Authors: Dong R, Wang J, Gao X, Wang C, Liu K, Wu J, Liu Z, Sun H, Ma X, Meng Q Tags: Eur J Pharmacol Source Type: research

Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor
ConclusionsYangonin protects against NAFLD due to its activation of FXR signalling to inhibit hepatic lipogenesis and gluconeogenesis, and to promote lipid metabolism and glycogen synthesis, as well as insulin sensitivity.Graphical abstract
Source: Phytomedicine - September 5, 2018 Category: Drugs & Pharmacology Source Type: research