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Yangonin protects against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner.
In conclusion, yangonin alleviates estrogen-induced cholestasis, due to FXR-mediated gene regulation. PMID: 31220436 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 16, 2019 Category: Drugs & Pharmacology Authors: Dong R, Wang J, Gao X, Wang C, Liu K, Wu J, Liu Z, Sun H, Ma X, Meng Q Tags: Eur J Pharmacol Source Type: research

Chalcone flavokawain A attenuates TGF- β1-induced fibrotic pathology via inhibition of ROS/Smad3 signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in vascular smooth muscle cells.
In this study, flavokawain A (FKA, 2-30 μM), a naturally occurring chalcone in kava extracts, was evaluated for its anti-fibrotic and antioxidant properties in TGF-β1-stimulated vascular smooth muscle (A7r5) cells, as well as its underlying molecular mechanism of action. Immunofluorescence data showed down-regulated F-actin expression with FKA treatment in TGF-β1-stimulated A7r5 cells. Western blotting demonstrated that FKA treatment suppressed the expression of α-SMA and fibronectin proteins under TGF-β1 stimulation. Findings from wound-healing and invasion experiments showed that FKA inhibits TGF-β1-mediated migra...
Source: J Cell Mol Med - December 13, 2018 Category: Molecular Biology Authors: Hseu YC, Yang TY, Li ML, Rajendran P, Mathew DC, Tsai CH, Lin RW, Lee CC, Yang HL Tags: J Cell Mol Med Source Type: research

Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor
ConclusionsYangonin protects against NAFLD due to its activation of FXR signalling to inhibit hepatic lipogenesis and gluconeogenesis, and to promote lipid metabolism and glycogen synthesis, as well as insulin sensitivity.Graphical abstract
Source: Phytomedicine - September 5, 2018 Category: Drugs & Pharmacology Source Type: research