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Autophagy-dependent apoptosis is triggered by a semi-synthetic 6-gingerol analogue in triple negative breast cancer cells.
In this study, we show that the semi-synthetic analogue SSi6, generated after chemical modification of the [6]-gingerol molecule, using acetone-2,4-dinitrophenylhydrazone (2,4-DNPH) reagent, enhanced selective cytotoxic effects on MDA-MB-231 cells. Remarkably, unlike the original [6]-gingerol molecule, SSi6 enabled autophagy followed by caspase-independent apoptosis in tumor cells. We found a time-dependent association between SSi6-induced oxidative stress, autophagy and apoptosis. Initial SSi6-induced reactive oxygen species (ROS) accumulation (1h) led to autophagy activation (2-6h), which was followed by caspase-independ...
Source: Oncotarget - August 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
Conclusions: These findings suggest that the reduction of cell viability and apoptosis by GL may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression through ERK1/2 activation in human colorectal cancer cells.
Source: BMC Complementary and Alternative Medicine - October 23, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHun Min SongHyun Ji EoMi Kyoung KimJin Wook LeeMan Hyo LeeKiu-Hyung ChoJeong Rak LeeHyeon Je ChoJin Boo Jeong Source Type: research

Abstract 3211: Citral is the major component of ginger-derived terpenes to mediate p53-dependent apoptosis in cancer cells
Steam distillation of ginger yields a mixture of twenty two terpenes. This mixture has anti-proliferative effect on over fifteen different human and mouse cancer cell lines tested in our previous studies. Since the mixture is heterogeneous, it cannot be developed into a therapeutic drug. Hence, we tested individual terpenes from the ginger extract to identify its bioactive component(s). Camphene and alpha-pinene together constitute 10% of the ginger terpene extract and have no effect on cancer cell proliferation. On the other hand, citral a mixture of the two isomers, neral and geranial which constitute 30-50% of the ginge...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Fass, L., Felder, M., Patankar, M. S., Kapur, A. K. Tags: Cancer Chemistry Source Type: research