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6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
Abstract Sepsis-induced liver injury is very common in intensive care units. Here, we investigated the effects of 6-gingerol on sepsis-induced liver injury and the role of the Nrf2 pathway in this process. 6-Gingerol is the principal ingredient of ginger that exerts anti-inflammatory and antioxidant effects. Using cecal ligation and puncture (CLP) to induce polymicrobial sepsis and related liver injury, we found that mice pre-treated with 6-Gingerol showed less incidences of severe liver inflammation and death than untreated CLP groups. 6-Gingerol administration also inhibited the expression of pyroptosis-related ...
Source: International Immunopharmacology - January 20, 2020 Category: Allergy & Immunology Authors: Hong MK, Hu LL, Zhang YX, Xu YL, Liu XY, He PK, Jia YH Tags: Int Immunopharmacol Source Type: research

Autophagy-dependent apoptosis is triggered by a semi-synthetic 6-gingerol analogue in triple negative breast cancer cells.
In this study, we show that the semi-synthetic analogue SSi6, generated after chemical modification of the [6]-gingerol molecule, using acetone-2,4-dinitrophenylhydrazone (2,4-DNPH) reagent, enhanced selective cytotoxic effects on MDA-MB-231 cells. Remarkably, unlike the original [6]-gingerol molecule, SSi6 enabled autophagy followed by caspase-independent apoptosis in tumor cells. We found a time-dependent association between SSi6-induced oxidative stress, autophagy and apoptosis. Initial SSi6-induced reactive oxygen species (ROS) accumulation (1h) led to autophagy activation (2-6h), which was followed by caspase-independ...
Source: Oncotarget - August 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis
Nanomedicine Ahead of Print.
Source: Future Medicine: Nanomedicine - June 30, 2017 Category: Nanotechnology Source Type: research

Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract
Publication date: June 2016 Source:Chinese Journal of Natural Medicines, Volume 14, Issue 6 Author(s): Meng-Qi YANG, Lin-Lan YE, Xiao-Ling LIU, Xiao-Ming QI, Jia-Di LV, Gang WANG, Ulah-Khan FARHAN, Nawaz WAQAS, Ding-Ding CHEN, Lei HAN, Xiao-Hui ZHOU TRPA1 channels are non-selective cation channels that could be activated by plant-derived pungent products, including gingerol, a main active constituent of ginger. Ginger could improve the digestive function; however whether ginger improves the digestive function through activating TRPA1 receptor in gastrointestinal tract has not been investigated. In the present ...
Source: Chinese Journal of Natural Medicines - July 26, 2016 Category: Complementary Medicine Source Type: research

Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
Conclusions: These findings suggest that the reduction of cell viability and apoptosis by GL may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression through ERK1/2 activation in human colorectal cancer cells.
Source: BMC Complementary and Alternative Medicine - October 23, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHun Min SongHyun Ji EoMi Kyoung KimJin Wook LeeMan Hyo LeeKiu-Hyung ChoJeong Rak LeeHyeon Je ChoJin Boo Jeong Source Type: research

Abstract 3211: Citral is the major component of ginger-derived terpenes to mediate p53-dependent apoptosis in cancer cells
Steam distillation of ginger yields a mixture of twenty two terpenes. This mixture has anti-proliferative effect on over fifteen different human and mouse cancer cell lines tested in our previous studies. Since the mixture is heterogeneous, it cannot be developed into a therapeutic drug. Hence, we tested individual terpenes from the ginger extract to identify its bioactive component(s). Camphene and alpha-pinene together constitute 10% of the ginger terpene extract and have no effect on cancer cell proliferation. On the other hand, citral a mixture of the two isomers, neral and geranial which constitute 30-50% of the ginge...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Fass, L., Felder, M., Patankar, M. S., Kapur, A. K. Tags: Cancer Chemistry Source Type: research