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Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer
Dose Response. 2021 Aug 2;19(3):15593258211033114. doi: 10.1177/15593258211033114. eCollection 2021 Jul-Sep.ABSTRACTNon-small-cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths. Radiotherapy remains the primary treatment method for NSCLC. Despite great advances in radiotherapy techniques and modalities, recurrence and resistance still limit therapeutic success, even low-dose ionizing radiation (IR) can induce the migration and invasion. Diallyl disulfide (DADS), a bioactive component extracted from garlic, exhibits a wide spectrum of biological activities including antitumor effects. However, the eff...
Source: Dose Response - August 16, 2021 Category: Drugs & Pharmacology Authors: Shuai Xu Hefa Huang Deping Tang Mengjie Xing Qiuyue Zhao Jianping Li Jing Si Lu Gan Aihong Mao Hong Zhang Source Type: research

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF- κB Pathways by Electrophilic/Non-Electrophilic Compounds
The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with the transcription factor NF-κB, a pivotal mediator of inflammatory responses and of multiple aspects of innate and adaptative immune functions. However, the underlying molecular basis has not been completely clarified. By combining into new chemical entities, the hydroxycinnamoyl motif from curcumin and the allyl mercaptan moiety of garlic organosulfur compounds, we tested a set...
Source: Frontiers in Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Source Type: research