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TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage
Neurochem Res. 2021 May 10. doi: 10.1007/s11064-021-03318-w. Online ahead of print.ABSTRACTReportedly, TWIK-related spinal cord K+ (TRESK) deficiency in spinal cord neurons positively correlates with the mechanism underlying neuropathic pain (NP). However, the precise effects of TRESK on neurons of the spinal cord remain elusive. In the present study, we investigated the impact of TRESK silencing on spinal cord neurons to further elucidate the downstream mechanisms of TRESK. Herein, neurons of the dorsal spinal cord were cultured as a cell model for investigations. Apoptosis, oxidative stress, and DNA damage-related protei...
Source: Neurochemical Research - May 11, 2021 Category: Neuroscience Authors: Pei Liu Ye Cheng Huiling Xu Haicheng Huang Simin Tang Fuhu Song Jun Zhou Source Type: research