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Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
In conclusion, our findings uncovered that I3A increased hepatic PGC1a expression, contributing to mitochondrial respiration improvement in NAFLD.PMID:35988807 | DOI:10.1016/j.cellsig.2022.110442
Source: Cellular Signalling - August 21, 2022 Category: Cytology Authors: Chen Zhang Qingsong Fu Kai Shao Limin Liu Xiaotian Ma Fengyi Zhang Xiaodong Zhang Liying Meng ChuanZhu Yan Xiaoyun Zhao Source Type: research

Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
Cell Signal. 2022 Jul 26:110419. doi: 10.1016/j.cellsig.2022.110419. Online ahead of print.ABSTRACTIntraplaque hemorrhage (IPH) accelerates atherosclerosis progression. To scavenge excessive red blood cells (RBCs), vascular smooth muscle cells (VSMCs) with great plasticity may function as phagocytes. Here, we investigated the erythrophagocytosis function of VSMCs and possible regulations involved. Based on transcriptional microarray analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that genes up-regulated in human carotid atheroma with IPH were enriched in functions of phagocytic activiti...
Source: Cellular Signalling - July 29, 2022 Category: Cytology Authors: Daorong Pan Wen Wu Guangfeng Zuo Xiangrong Xie Hui Li Xiaomin Ren Chaohua Kong Wenying Zhou Zihan Zhang Martin Waterfall Shaoliang Chen Source Type: research

IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation
Cell Signal. 2021 Jul 9:110082. doi: 10.1016/j.cellsig.2021.110082. Online ahead of print.ABSTRACTGlomerular hypertrophy is a crucial factor of severe podocyte damage and proteinuria. Our previous study showed that high fructose induced podocyte injury. The current study aimed to explore a novel molecular mechanism underlying podocyte hypertrophy induced by high fructose. Here we demonstrated for the first time that high fructose significantly initiated the hypertrophy in rat glomeruli and differentiated human podocytes (HPCs). Consistently, it induced inflammatory response with the down-regulation of anti-inflammatory fac...
Source: Cellular Signalling - July 12, 2021 Category: Cytology Authors: Jie Zhou Jie Yang Yu-Meng Wang Hong Ding Tu-Shuai Li Zhi-Hong Liu Li Chen Rui-Qing Jiao Dong-Mei Zhang Ling-Dong Kong Source Type: research

Coordinated regulation of miR-27 by insulin/CREB/Hippo contributes to insulin resistance.
In this study, we attempted to identify the mechanism by which miR-27 was regulated in the context of insulin resistance, a predisposed metabolic disorder in NAFLD. With cell culture experiments and animal studies, our results showed that miR-27 was coordinately regulated by insulin, CREB, and Hippo signalings. First, miR-27 was upregulated in palmitate-treated cells and high fat diet-fed mouse livers, both of which exhibited insulin resistance and increased CREB expression. Second, miR-27 was peaked in mouse liver at post-absorptive phase when CREB activity was increased. Also, miR-27 was increased rapidly in insulin-trea...
Source: Cellular Signalling - January 27, 2021 Category: Cytology Authors: Chen YJ, Chueh LY, Lee SY, Ma PF, Chen PC, Hsu SH Tags: Cell Signal Source Type: research