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Survival Motor Neuron (SMN) Protein Insufficiency Exacerbates Renal Ischemia/Reperfusion Injury
The survival of motor neuron (SMN) protein is ubiquitously involved in spliceosome assembly and ribonucleoprotein biogenesis. SMN protein is expressed in kidney and can affect cell death processes. However, the role of SMN in acute kidney injury is largely unknown. In the current study, we found that the expression of SMN in the kidney was significantly reduced in both clinical ischemic acute kidney injury (AKI) and a mouse model of renal ischemia-reperfusion injury (IRI). We then used SMN heterozygous knockout (SMN+/-) mice and found that the declines in renal function, tubular injury, and tubular cell apoptosis after exp...
Source: Frontiers in Physiology - May 13, 2019 Category: Physiology Source Type: research