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Source: Acta Pharmacologica Sinica
Nutrition: Cinnamon
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Total 3 results found since Jan 2013.
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells
Acta Pharmacol Sin. 2021 May 12. doi: 10.1038/s41401-021-00672-x. Online ahead of print.ABSTRACTPrevious reports suggested that cinnamaldehyde (CA), the bioactive ingredient in Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities. However, the role and molecular mechanisms of CA in GC are not completely understood. In the present study, we found that CA-induced ER stress and cell death via the PERK-CHOP axis and Ca2+ release in GC cells. Inhibition of ER stress using specific-siRNA blocked CA-induced cell death. Interestingly, CA treatment resulted in autophagic cell death by inducing Beclin-1, A...
Source: Acta Pharmacologica Sinica - May 13, 2021 Category: Drugs & Pharmacology Authors: Tae Woo Kim Source Type: research
