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Blueberry anthocyanins ameliorate radiation-induced lung injury through the protein kinase RNA-activated pathway.
Abstract The purpose of this study was to explore the effect of blueberry anthocyanins (BA) on radiation-induced lung injury and investigate themechanism of action. Seven days after BA(20 and 80 mg/kg/d)administration, 6 weeks old male Sprague-Dawley ratsrats were irradiated by LEKTA precise linear accelerator at a single dose of 20 Gy only once. and the rats were continuously treated with BA for 4 weeks. Moreover, human pulmonary alveolar epithelial cells (HPAEpiC) were transfected with either control-siRNA or siRNA targeting protein kinase R (PKR). Cells were then irradiated and treated with 75 μg/mL BA for 72 ...
Source: Chemico-Biological Interactions - November 6, 2015 Category: Molecular Biology Authors: Liu Y, Tan D, Tong C, Zhang Y, Xu Y, Liu X, Gao Y, Hou M Tags: Chem Biol Interact Source Type: research