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Pterostilbene, A Bioactive Component of Blueberries, Alleviates Renal Interstitial Fibrosis by Inhibiting Macrophage-Myofibroblast Transition.
In this study, we investigated the antifibrotic effects of PTB on the in vivo mouse unilateral ureteral obstruction (UUO) model and in vitro MMT cells. Kidneys subjected to UUO with PTB treatment were collected for the investigation of PTB mediating MMT derived renal interstitial fibrosis. We conducted kidney RNA-seq transcriptomes and TGF-[Formula: see text]1-induced bone marrow-derived macrophages assays to determine the mechanisms of PTB. We found that PTB treatment suppressed the interstitial fibrosis in UUO mice. PTB also attenuated the number of MMT cells in vivo and in vitro. The transcriptomic analysis showed that ...
Source: The American Journal of Chinese Medicine - November 5, 2020 Category: Complementary Medicine Authors: Feng Y, Guo F, Mai H, Liu J, Xia Z, Zhu G, Zhang J, Ma L, Fu P Tags: Am J Chin Med Source Type: research

Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress
Conclusions: Overall, the results indicate that PTE is a potent anti-cancer pharmaceutical against human esophageal cancer, and the possible mechanism involves the activation of ERS signaling pathways.Cell Physiol Biochem 2016;38:1226-1244
Source: Cellular Physiology and Biochemistry - March 16, 2016 Category: Cytology Source Type: research

Abstract B17: Epigenetic regulation of NOTCH oncogenic signaling in breast cancer
Alterations in DNA methylation occur at different stages of cancer, including initiation, and may underlie up-regulation of genes with oncogenic functions. The NOTCH pathway is often overactive in breast cancer and plays roles in cancer development and progression. It is therefore a possible target for anti-cancer strategies. However, the mechanisms of NOTCH regulation in mammary carcinogenesis remain unclear which hinders the development of effective approaches to target this oncogenic pathway. Interestingly, certain dietary compounds such as polyphenols with a stilbenoid structure suppress the NOTCH signals in cancer and...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Lubecka, K., Kurzava, L., Flower, K., Buvala, H., Teegarden, D., Camarillo, I., Flanagan, J. M., Stefanska, B. Tags: Cancer Genomics and Epigenomics Source Type: research

Blueberry anthocyanins ameliorate radiation-induced lung injury through the protein kinase RNA-activated pathway
Publication date: Available online 6 November 2015 Source:Chemico-Biological Interactions Author(s): Yunen Liu, Dehong Tan, Changci Tong, Yubiao Zhang, Ying Xu, Xinwei Liu, Yan Gao, Mingxiao Hou The purpose of this study was to explore the effect of blueberry anthocyanins (BA) on radiation-induced lung injury and investigate themechanism of action. Seven days after BA(20 and 80 mg/kg/d)administration, 6 weeks old male Sprague–Dawley ratsrats were irradiated by LEKTA precise linear accelerator at a single dose of 20 Gy only once. and the rats were continuously treated with BA for 4 weeks. Moreover, human pulmona...
Source: Chemico Biological Interactions - November 7, 2015 Category: Biochemistry Source Type: research

Blueberry anthocyanins ameliorate radiation-induced lung injury through the protein kinase RNA-activated pathway.
Abstract The purpose of this study was to explore the effect of blueberry anthocyanins (BA) on radiation-induced lung injury and investigate themechanism of action. Seven days after BA(20 and 80 mg/kg/d)administration, 6 weeks old male Sprague-Dawley ratsrats were irradiated by LEKTA precise linear accelerator at a single dose of 20 Gy only once. and the rats were continuously treated with BA for 4 weeks. Moreover, human pulmonary alveolar epithelial cells (HPAEpiC) were transfected with either control-siRNA or siRNA targeting protein kinase R (PKR). Cells were then irradiated and treated with 75 μg/mL BA for 72 ...
Source: Chemico-Biological Interactions - November 6, 2015 Category: Molecular Biology Authors: Liu Y, Tan D, Tong C, Zhang Y, Xu Y, Liu X, Gao Y, Hou M Tags: Chem Biol Interact Source Type: research

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF‐κB/microRNA 448 circuit
ConclusionPterostilbene effectively suppresses the generation of CSCs and metastatic potential under the influence of M2 TAMs via modulating EMT associated signaling pathways, specifically NF‐κB/miR488 circuit. Thus, pterostilbene could be an ideal anti‐CSC agent in clinical settings.
Source: Nahrung / Food - March 15, 2013 Category: Nutrition Authors: Ka‐Kit Mak, Alexander T. H. Wu, Wei‐Hwa Lee, Tung‐Cheng Chang, Jeng‐Fong Chiou, Liang‐Shun Wang, Chih‐Hsiung Wu, Chi‐Ying F. Huang, Yi‐Shing Shieh, Tsu‐Yi Chao, Chi‐Tang Ho, Gow‐Chin Yen, Chi‐Tai Yeh Tags: Research Article Source Type: research