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Drug: Estradiol
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Total 2 results found since Jan 2013.
17 {beta}-Estradiol promotes vascular endothelial growth factor expression via the Wnt/{beta}-catenin pathway during the pathogenesis of endometriosis
STUDY HYPOTHESIS
Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis and how?
STUDY FINDING
17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF in effector human primary endometrial stromal cells (ESCs) and thus enhances their ability to establish a new blood supply to the human exfoliated endometrium.
WHAT IS KNOWN ALREADY
Implantation and survival of exfoliated endometrium is crucially dependent on neovascularization and Wnt/β-catenin signaling plays an important role in stimulating angiogenesis.
STUDY DESIGN, SAMPLES...
Source: Molecular Human Reproduction - July 11, 2016 Category: Molecular Biology Authors: Zhang, L., Xiong, W., Xiong, Y., Liu, H., Liu, Y. Tags: Original Research Source Type: research
MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos
STUDY QUESTION
Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation?
SUMMARY ANSWER
Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts.
WHAT IS KNOWN ALREADY
The Let-7a microRNA is up-regulated during blastocyst dormancy and its forced-expression suppresses embryo implantation in vitro and in vivo. Dicer is a Let-7 target, which processes pre-microRNA to mature microRNA.
STUDY DESIGN, SIZE, DURATION
The effects on the expression of Let-7a and dicer in d...
Source: Human Reproduction - March 11, 2014 Category: Reproduction Medicine Authors: Cheong, A. W. Y., Pang, R. T. K., Liu, W.-M., Kottawatta, K. S. A., Lee, K.-F., Yeung, W. S. B. Tags: Reproductive biology Source Type: research