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Total 3 results found since Jan 2013.
HMGB1-NLRP3-P2X7R pathway participates in PM < sub > 2.5 < /sub > -induced hippocampal neuron impairment by regulating microglia activation
In this study, we focused on the role of HMGB1-NLRP3-P2X7R pathway which mediated the microglia activation in hippocampal neurons impairment induced by PM2.5 using a co-culture model of microglia and hippocampal neurons. We found that PM2.5 resulted in activated microglia and HMGB1-NLRP3 inflammatory pathway, and elevated proinflammatory cytokines of IL-18 and IL-1β in a dose-dependent manner. Notably, we next utilized previously reported pharmacological inhibitors or siRNA for HMGB1 and found that they significantly inhibited the activation of downstream NLRP3 and MAPK pathways derived from PM2.5 exposure, and down-regul...
Source: Ecotoxicology and Environmental Safety - May 23, 2022 Category: Environmental Health Authors: Chong Liu Yingjie She Jia Huang Yongping Liu Wanwei Li Can Zhang Tianliang Zhang Li Yu Source Type: research
