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Source: PLoS Neglected Tropical Diseases
Infectious Disease: Yellow Fever
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Characterization of the Zika virus induced small RNA response in < i > Aedes aegypti < /i > cells
by Margus Varjak, Claire L. Donald, Timothy J. Mottram, Vattipally B. Sreenu, Andres Merits, Kevin Maringer, Esther Schnettler, Alain Kohl
RNA interference (RNAi) controls arbovirus infections in mosquitoes. Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the production of virus-derived small RNAs of 25–29 and 21 nucleotides, respectively. The exo-siRNA pathway is considered to be the key mosquito antiviral response mechanism. InAedes aegypti-derived cells, Zika virus (ZIKV)-specific siR...
Source: PLoS Neglected Tropical Diseases - October 17, 2017 Category: Tropical Medicine Authors: Margus Varjak Source Type: research
