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Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion.
We examined the effects of NSP4 and glucose on sodium and chloride transport in mouse small intestines and Caco-2 cells. Mouse small intestines and Caco-2 cells were incubated with NSP4114-135 in the presence/absence of glucose. Absorption and secretion of sodium and chloride, fluid movement, peak amplitude of intracellular calcium fluorescence, and expression of Ano1 and sodium-glucose cotransporter 1 were assessed. NHE3 activity increased, and chloride secretory activity decreased with age. Net chloride secretion increased, and net sodium absorption decreased in the intestines of 3-week-old mice compared to 8-week-old mi...
Source: Pflugers Archiv : European Journal of Physiology - May 10, 2017 Category: Physiology Authors: Yin L, Menon R, Gupta R, Vaught L, Okunieff P, Vidyasagar S Tags: Pflugers Arch Source Type: research