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Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni
Conclusion: We conclude that CiaD is involved in the activation of Erk 1/2 and that activated Erk 1/2 facilitates C. jejuni invasion by phosphorylation of cortactin on serine 405 and 418. This is the first time that cortactin and N-WASP have been shown to be involved in C. jejuni invasion of host cells. These data also provide a mechanistic basis for the requirement of Erk 1/2 in C. jejuni-mediated cytoskeletal rearrangement.
Source: Cell Communication and Signaling - November 4, 2013 Category: Molecular Biology Authors: Derrick SamuelsonMichael Konkel Source Type: research