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Invasion of epithelial cells by Campylobacter jejuni is independent of caveolae
: Caveolae are 25-100 nm flask-like membrane structures enriched in cholesterol and glycosphingolipids. Researchers have proposed that Campylobacter jejuni require caveolae for cell invasion based on the finding that treatment of cells with the cholesterol-depleting compounds filipin III or methyl-beta-cyclodextrin (MbetaCD) block bacterial internalization in a dose-dependent manner. The purpose of this study was to determine the role of caveolae and caveolin-1, a principal component of caveolae, in C. jejuni internalization. Consistent with previous work, we found that the treatment of HeLa cells with MbetaCD inhibited C....
Source: Cell Communication and Signaling - December 23, 2013 Category: Molecular Biology Authors: Michael KonkelDerrick SamuelsonTyson EuckerEric SheldenJason O'Loughlin Source Type: research

Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni
Conclusion: We conclude that CiaD is involved in the activation of Erk 1/2 and that activated Erk 1/2 facilitates C. jejuni invasion by phosphorylation of cortactin on serine 405 and 418. This is the first time that cortactin and N-WASP have been shown to be involved in C. jejuni invasion of host cells. These data also provide a mechanistic basis for the requirement of Erk 1/2 in C. jejuni-mediated cytoskeletal rearrangement.
Source: Cell Communication and Signaling - November 4, 2013 Category: Molecular Biology Authors: Derrick SamuelsonMichael Konkel Source Type: research