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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.
Abstract Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimates the complexity of downstream signalling events. To address this gap, we use mass spectrometry-based chemical proteomics to characterize the global impact of an oncogene on the expressed kinome, and then functionally annotate the regulated kinases. As an example, we identify 63 protein kinases exhibiting altered expression and/or phosphorylation in Src-transformed mammary epithelial cells. An integrated siRNA screen identifies nine kinases, including SGK1, as being essential ...
Source: Genomics Proteomics ... - January 17, 2019 Category: Genetics & Stem Cells Authors: Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ Tags: Nat Commun Source Type: research

Abstract 3294: Notch signaling is regulated by vacuolar ATPase in triple negative breast cancer
Triple Negative Breast Cancer (TNBC) constitutes 15 % of all diagnosed breast cancers. It is more common among African American and younger women. TNBC cells do not express Estrogen, Progesterone and Her2 receptors. As a result, patients have limited treatment options. To effectively treat TNBC, it is important to identify and target specific signaling pathways that contribute to TNBC tumorigenesis. Notch signaling is an evolutionarily conserved juxtacrine pathway that is important in normal mammary development and has been shown to play a role in TNBC progression. Although there has been considerable research on role of N...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Pamarthy, S., Beaman, K. D. Tags: Molecular and Cellular Biology Source Type: research