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Controlling HCV infection by targeting its translation initiation site in PBMCs using siRNA; In Vitro.
Abstract Hepatitis C virus infection and its complications are among the leading public health challenges, the emergence of drug-resistant variants is expected to be a major problem. A combinatorial small interfering RNA (siRNA) could be a novel triple therapy that could be suitable for genotype 4. HCV believed to be hepatotropic, but there is liable evidence about its replication in peripheral blood mononuclear cells (PBMC) of chronic HCV infected patients. These cells act as an extra-hepatic reservoir for viral recurrence and persistence, patients with HCV-RNA in PBMC showed a significantly lower response to the...
Source: Infectious Disorders Drug Targets - November 14, 2018 Category: Infectious Diseases Authors: Youssef SS, Elemeery MN, Eldein SS, Ghareeb DA Tags: Infect Disord Drug Targets Source Type: research

The Antiviral Role of Zinc and Metallothioneins in Hepatitis C Infection
This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - December 1, 2017 Category: Infectious Diseases Authors: Scott A Read, Grant Parnell, David Booth, Mark W Douglas, Jacob George, Golo Ahlenstiel Tags: Original Paper Source Type: research

Alpha ‐enolase regulates hepatitis B virus replication through suppression of the interferon signalling pathway
Summary Persistent chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of HBV‐related diseases. The molecular mechanisms that underlie HBV infection and associated carcinogenesis are not fully understood. The aim of this study was to explore the role of ENO1 in HBV replication processes. Here, we examined ENO1 expression levels in HBV‐infected and non‐HBV‐infected liver tissues and cells by Western blot analysis, real‐time PCR and immunohistochemistry. In addition, HBsAg and HBeAg in the media of transfected HepG2.2.15 cells were detected using an electrochemical luminescence...
Source: Journal of Viral Hepatitis - November 20, 2017 Category: Infectious Diseases Authors: D. Xiang ‐Chun, Y. Xiao‐qing, Y. Ting‐Ting, L. Zhen‐Hui, L. Xiao‐Yan, L. Xia, H. Yan‐Chao, Y. Yi‐Xuan, M. Li‐Na Tags: ORIGINAL ARTICLE Source Type: research

ENO1 (alpha ‐enolase) Regulates HBV Replication through Suppression of the IFN Signaling Pathway
This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - October 27, 2017 Category: Infectious Diseases Authors: Ding Xiang ‐Chun, Yang Xiao‐qing, Yan Ting‐Ting, Lu Zhen‐Hui, Liu Xiao‐Yan, Luo Xia, Hu Yan‐Chao, Yang Yi‐Xuan, Ma Li‐Na Tags: Original Paper Source Type: research

Targeting Human Telomerase Reverse Transcriptase by a Simple siRNA Expression Cassette in HepG2 Cells
Conclusions: Our developed simple SEC was a powerful strategy for screening highly effective RNAi-targeted sequences and showed promise for gene therapy of HCC.
Source: Hepatitis Monthly - March 30, 2015 Category: Infectious Diseases Source Type: research

Hepatitis B virus x protein induces autophagy via activating death‐associated protein kinase
In conclusion, HBX induces autophagy via activating DAPK in a pathway related to Beclin 1, but not JNK. This new finding should help us to understand the role of autophagy in HBX‐mediated pathogenesis and thus may provide targets for intervening HBX‐related disorders.
Source: Journal of Viral Hepatitis - November 4, 2013 Category: Infectious Diseases Authors: H.‐T Zhang, G. G. Chen, B.‐G. Hu, Z.‐Y. Zhang, J.‐P Yun, M.‐L. He, P. B. S. Lai Tags: Original Article Source Type: research