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Source: Am J Physiol Lung Ce...
Infectious Disease: Bird Flu
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Total 1 results found since Jan 2013.
Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-κB and p38 MAPK signaling pathways.
Abstract
Since avian influenza virus H5N1-induced hypercytokemia plays a key role in acute lung injury, understanding its molecular mechanism is highly desirable for discovering therapeutic targets against H5N1 infection. In the present study, we investigated the role of autophagy in H5N1-induced lung inflammation by using H5N1 hemagglutinin pseudotyped viral particles (H5N1pps). The results showed that H5N1pps significantly induced autophagy both in A549 human lung epithelial cells and in mouse lung tissues, which was primarily due to hemagglutinin (HA) of H5N1 virus. Blocking autophagy with 3-MA (an autophagy in...
Source: Am J Physiol Lung Ce... - November 15, 2013 Category: Respiratory Medicine Authors: Pan H, Zhang Y, Luo Z, Li P, Liu L, Wang C, Wang H, Li H, Ma Y Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
