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Persistent Escherichia coli infection in renal tubular cells enhances calcium oxalate crystal-cell adhesion by inducing ezrin translocation to apical membranes via Rho/ROCK pathway
In this study, Escherichia coli, the most common bacterium found in recurrent UTI was used to establish the in vitro model for persistent infection of renal epithelial cells. The promoting effects of persistent E. coli infection on kidney stone formation were validated by COM crystal-cell adhesion assay, followed by immunofluorescence study for changes in surface expression of the known COM crystal receptors. Among the five receptors examined, only ezrin had significantly increased level on the surface of persistently infected cells without change in its total level. Such translocation of ezrin to apical membranes was conf...
Source: Cellular and Molecular Life Sciences : CMLS - June 24, 2022 Category: Cytology Authors: Rattiyaporn Kanlaya Visith Thongboonkerd Source Type: research

SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
Conclusions: In conclusion, our results suggest that SIGIRR plays an important role in the negative regulation of LPS response and tolerance in human bladder epithelial cells, possibly through its impact on TLR-mediated signaling.
Source: BMC Immunology - December 3, 2015 Category: Allergy & Immunology Authors: Dan LiXin ZhangBaiyi Chen Source Type: research