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Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis.
Abstract Enteropathogenic Escherichia coli (EPEC) uses a type III secretion system (T3SS) to directly translocate effector proteins into host cells where they play a pivotal role in subverting host cell signaling needed for disease. However, our knowledge of how EPEC affects host protein phosphorylation is limited to a few individual protein studies. We employed a quantitative proteomics approach to globally map alterations in the host phosphoproteome during EPEC infection. By characterizing host phosphorylation events at various time points throughout infection, we examined how EPEC dynamically impacts the host p...
Source: Molecular and Cellular Proteomics : MCP - May 5, 2015 Category: Molecular Biology Authors: Scholz R, Imami K, Scott NE, Trimble WS, Foster LJ, Finlay BB Tags: Mol Cell Proteomics Source Type: research