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Viruses, Vol. 15, Pages 1629: Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response
In this study, we observed that various porcine innate immune signaling adaptors are involved in anti-PEDV (AJ1102-like strain) activity in transfected Vero cells. Among these, TRIF and MAVS showed the strongest anti-PEDV activity. The endogenous TRIF, MAVS, and STING were selected for further examination of anti-PEDV activity. Agonist stimulation experiments showed that TRIF, MAVS, and STING signaling all have obvious anti-PEDV activity. The siRNA knockdown assay showed that TRIF, MAVS, and STING are also all involved in anti-PEDV response, and their remarkable effects on PEDV replication were confirmed in TRIF&mi...
Source: Viruses - July 26, 2023 Category: Virology Authors: Youwen Zhang Yulin Xu Sen Jiang Shaohua Sun Jiajia Zhang Jia Luo Qi Cao Wanglong Zheng Fran çois Meurens Nanhua Chen Jianzhong Zhu Tags: Article Source Type: research